Long-term health and germline transmission in transgenic cattle following transposon-mediated gene transfer

Long-term health and germline transmission in transgenic cattle following transposon-mediated gene transfer

Abstract Background Transposon-mediated, non-viral gene delivery is a powerful tool for generating stable cell lines and transgenic animals. However, as multi-copy insertion is the preferred integration pattern, there is the potential for uncontrolled changes in endogenous gene expression and detrim...

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Bibliographic Details
Main Authors: Soo-Young Yum, Song-Jeon Lee, Sin-Gi Park, In-Gang Shin, Sang-Eun Hahn, Woo-Jae Choi, Hee-Soo Kim, Hyeong-Jong Kim, Seong-Hun Bae, Je-Hyeong Lee, Joo-Yeong Moon, Woo-Sung Lee, Ji-Hyun Lee, Choong-Il Lee, Seong-Jin Kim, Goo Jang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Genomics
Subjects:
Germline transmission
Next-generation sequencing
Sleeping beauty
PiggyBac
Transgenic cattle
Online Access:http://link.springer.com/article/10.1186/s12864-018-4760-4

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http://link.springer.com/article/10.1186/s12864-018-4760-4

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