The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Summary: Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell types. Here, we characterize GR’s protein intera...

Full description

Bibliographic Details
Main Authors: Franziska Greulich, Michael Wierer, Aikaterini Mechtidou, Omar Gonzalez-Garcia, N. Henriette Uhlenhaut
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
glucocorticoid receptor
dexamethasone
macrophages
inflammation
SETD1A
COMPASS complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000553

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721000553

Similar Items