Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia.

The adapter protein metastasis suppressor 1 (MTSS1) is implicated as a tumor suppressor or tumor promoter, depending on the type of solid cancer. Here, we identified Mtss1 expression to be increased in AML subsets with favorable outcome, while suppressed in high risk AML patients. High expression of...

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Main Authors: Mirle Schemionek, Behzad Kharabi Masouleh, Yvonne Klaile, Utz Krug, Katja Hebestreit, Claudia Schubert, Martin Dugas, Thomas Büchner, Bernhard Wörmann, Wolfgang Hiddemann, Wolfgang E Berdel, Tim H Brümmendorf, Carsten Müller-Tidow, Steffen Koschmieder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4440712?pdf=render