The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia

The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia

Chronic kidney disease (CKD) is characterized by the progressive loss of renal function; moreover, CKD progression commonly leads to multiple comorbidities, including neurological dysfunction and immune disorders. CKD-triggered neuroinflammation significantly contributes to cognitive impairment. Thi...

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Bibliographic Details
Main Authors: Lung-Chih Li, Wei-Yu Chen, Jin-Bor Chen, Wen-Chin Lee, Chiung-Chih Chang, Hong-Tai Tzeng, Chiang-Chi Huang, Ya-Jen Chang, Jenq-Lin Yang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
chronic kidney disease
cognitive impairment
indoxyl sulfate
inflammation
NLRP3
astrocyte
Online Access:https://www.mdpi.com/2227-9059/9/9/1252

Internet

https://www.mdpi.com/2227-9059/9/9/1252

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