HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

Abstract Objective To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients. Methods We conducted a prospective study in 28 HIV/HCV-coinfected patients receiving IFN-based...

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Bibliographic Details
Main Authors: Óscar Brochado, Isidoro Martínez, Juan Berenguer, Luz Medrano, Juan González-García, María Ángeles Jiménez-Sousa, Ana Carrero, Víctor Hontañón, Jordi Navarro, Josep M. Guardiola, Amanda Fernández-Rodríguez, Salvador Resino, the GESIDA Study Group
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Biomedical Science
Subjects:
HIV/HCV coinfection
Gene expression
Immune system
HCV clearance
Interferon therapy
PBMCs
Online Access:https://doi.org/10.1186/s12929-021-00718-6

Internet

https://doi.org/10.1186/s12929-021-00718-6

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