Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABA<sub>A</sub> Receptor Activation

Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABA<sub>A</sub> Receptor Activation

Rosmarinic acid, a major component of rosemary, is a polyphenolic compound with potential neuroprotective effects. Asreducing the synaptic release of glutamate is crucial to achieving neuroprotectant’s pharmacotherapeutic effects, the effect of rosmarinic acid on glutamate release was investigated i...

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Bibliographic Details
Main Authors: Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kuo, Su-Jane Wang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
rosmarinic acid
glutamate release
GABA<sub>A</sub> receptor
voltage-gated Ca<sup>2+</sup> channel
CaMKII
synapsin I
Online Access:https://www.mdpi.com/2218-273X/11/7/1029

Internet

https://www.mdpi.com/2218-273X/11/7/1029

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