Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation

Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation

Brain volume measurements extracted from structural MRI data sets are a widely accepted neuroimaging biomarker to study mouse models of neurodegeneration. Whether to acquire and analyze data in vivo or ex vivo is a crucial decision during the phase of experimental designs, as well as data analysis....

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Bibliographic Details
Main Authors: Da Ma, Holly E. Holmes, Manuel J. Cardoso, Marc Modat, Ian F. Harrison, Nick M. Powell, James M. O’Callaghan, Ozama Ismail, Ross A. Johnson, Michael J. O’Neill, Emily C. Collins, Mirza F. Beg, Karteek Popuri, Mark F. Lythgoe, Sebastien Ourselin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Neuroscience
Subjects:
in vivo
ex vivo
structural parcellation
longitudinal
disease progression
treatment effect
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00011/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00011/full

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