Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

Abstract Background MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of pre...

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Bibliographic Details
Main Authors: Ibrahim M. Shokry, Connor J. Shields, John J. Callanan, Zhiyuan Ma, Rui Tao
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
MDMA toxicity
Serotonin syndrome
Serotonergic injury
Hypothermia
Hyperthermia
Microdialysis
Online Access:http://link.springer.com/article/10.1186/s40360-019-0326-6

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http://link.springer.com/article/10.1186/s40360-019-0326-6

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