Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.

Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.

Enhanced lysosomal trafficking is associated with metastatic cancer. In an attempt to discover cancer relevant lysosomal motor proteins, we compared the lysosomal proteomes from parental MCF-7 breast cancer cells with those from highly invasive MCF-7 cells that express an active form of the ErbB2 (D...

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Bibliographic Details
Main Authors: Carla M P Cardoso, Line Groth-Pedersen, Maria Høyer-Hansen, Thomas Kirkegaard, Elizabeth Corcelle, Jens S Andersen, Marja Jäättelä, Jesper Nylandsted
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2647799?pdf=render

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http://europepmc.org/articles/PMC2647799?pdf=render

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