An in vitromodel to quantify interspecies differences in kinetics for intestinal microbial bioactivation and detoxification of zearalenone

Zearalenone (ZEN) is a mycotoxin known for its estrogenic activities. The metabolism of ZEN plays a role in the interspecies differences in sensitivity to ZEN, and is known to occur in the liver and via the intestinal microbiota, although the relative contribution of these two pathways remains to be...

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Bibliographic Details
Main Authors: Diana M. Mendez-Catala, Albertus Spenkelink, Ivonne M.C.M. Rietjens, Karsten Beekmann
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020303553