One-pot aminobenzylation of aldehydes with toluenes

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diaryle...

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Bibliographic Details
Main Authors: Zhiting Wang, Zhipeng Zheng, Xinyu Xu, Jianyou Mao, Patrick J. Walsh
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05638-y