Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this area, perhaps the most utilized technology to date...

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Bibliographic Details
Main Authors: Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
CRISPR
Cas9
Transgenic mice
Metabolism
Tissue specific
Phenotype
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782100137X

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http://www.sciencedirect.com/science/article/pii/S221287782100137X

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