Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome

Serotonin 5-HT7 receptors are expressed in the hippocampus and modulate the excitability of hippocampal neurons. We have previously shown that 5-HT7 receptors modulate glutamate-mediated hippocampal synaptic transmission and long-term synaptic plasticity. In particular, we have shown that activation...

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Bibliographic Details
Main Authors: Lara eCosta, Lara Maria Sardone, Enza eLacivita, Marcello eLeopoldo, Lucia eCiranna
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Fragile X Syndrome
Hippocampus
5-HT7
MGluR-LTD
5-HT7R agonist
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00065/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00065/full

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