The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions

The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions

Circulating platelets establish a variety of immunological programs and orchestrate inflammatory responses at the endothelium. Platelets express the innate immunity family of Toll-like receptors (TLRs). While TLR2/TLR1 ligands are known to activate platelets, the effects of TLR2/TLR6 ligands on plat...

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Bibliographic Details
Main Authors: Iván Parra-Izquierdo, Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Jiaqing Pang, Tony J. Zheng, Kelley R. Jordan, Stéphanie E. Reitsma, Owen J. T. McCarty, Joseph E. Aslan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
platelets
Pam2CSK4
TLR2
adhesion
BTK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729951/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.729951/full

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