Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation

Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation

<p>Abstract</p> <p>Objectives</p> <p>To study the hypothesis that gemcitabine treatment augments the chemoresistance to gemcitabine by clusterin (sCLU) upregulation. Clusterin inhibition could augment the chemosensitivity of human pancreatic cancer cells by inhibition o...

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Bibliographic Details
Main Authors: Tang Yong, Liu Fenghua, Zheng Chunning, Sun Shaochuan, Jiang Yingsheng
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Chemoresistance
Gemcitabine
Gene treatment
Clusterin;ERK1/2
Online Access:http://www.jeccr.com/content/31/1/73

Internet

http://www.jeccr.com/content/31/1/73

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