A nitric oxide-releasing prodrug promotes apoptosis in human renal carcinoma cells: Involvement of reactive oxygen species

A nitric oxide-releasing prodrug promotes apoptosis in human renal carcinoma cells: Involvement of reactive oxygen species

JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate group that shows pronounced cytotoxicity and antitumor properties in numerous cancer models, including in vitro as well as in vivo. Reactive oxygen species (ROS) induce carcinogenesis by altering the redox status, caus...

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Bibliographic Details
Main Authors: Xie Jindong, Chen Lieqian, Huang Dongqiang, Yue Weiwei, Chen Jingyu, Liu Chunxiao
Format: Article
Language:English
Published: De Gruyter 2021-05-01
Series:Open Chemistry
Subjects:
apoptosis
ros
js-k
nitric oxide
renal carcinoma cells
Online Access:https://doi.org/10.1515/chem-2020-0075

Internet

https://doi.org/10.1515/chem-2020-0075

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