Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathwayResearch in context

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathwayResearch in context

Background: Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver cancer, which are considered to be responsible for tumor relapse, metastasis, and chemoresistance. However, novel therapeu...

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Bibliographic Details
Main Authors: Binghua Li, Yajuan Cao, Gang Meng, Liyuan Qian, Tiancheng Xu, Chen Yan, Ouyang Luo, Shaohe Wang, Jiwu Wei, Yitao Ding, Decai Yu
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641830567X

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http://www.sciencedirect.com/science/article/pii/S235239641830567X

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