Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

Calmodulin (CaM) serves as a pervasive regulatory subunit of CaV1, CaV2, and NaV1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca2+-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters functional adaptability, as global...

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Bibliographic Details
Main Authors: Jacqueline Niu, Ivy E Dick, Wanjun Yang, Moradeke A Bamgboye, David T Yue, Gordon Tomaselli, Takanari Inoue, Manu Ben-Johny
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
Ca channels
Na channels
calmodulin
fibroblast growth factor homologous factors
SH3 and cysteine rich domain proteins
calcium regulation
Online Access:https://elifesciences.org/articles/35222

Internet

https://elifesciences.org/articles/35222

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