How does cross-reactive stimulation affect the longevity of CD8+ T cell memory?

Immunological memory--the ability to "remember" previously encountered pathogens and respond faster upon re-exposure is a central feature of the immune response in vertebrates. The cross-reactive stimulation hypothesis for the maintenance of memory proposes that memory cells specific for a...

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Bibliographic Details
Main Authors: Vitaly V Ganusov, Sergei S Pilyugin, Rafi Ahmed, Rustom Antia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC1475713?pdf=render