Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways

Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways

ObjectiveHuangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative co...

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Bibliographic Details
Main Authors: Min-yao Li, Hui-juan Luo, Xue Wu, Yu-hong Liu, Yu-xuan Gan, Nan Xu, Yao-min Zhang, Shu-hua Zhang, Chang-lin Zhou, Zi-ren Su, Xiao-qi Huang, Xue-bao Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
Huangqin decoction
gut microbiota
Ras-PI3K-Akt-HIF-1α pathway
NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01552/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01552/full

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