An in-silico human cell model reveals the influence of spatial organization on RNA splicing.

Spatial organization is a characteristic of all cells, achieved in eukaryotic cells by utilizing both membrane-bound and membrane-less organelles. One of the key processes in eukaryotes is RNA splicing, which readies mRNA for translation. This complex and highly dynamical chemical process involves a...

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Bibliographic Details
Main Authors: Zhaleh Ghaemi, Joseph R Peterson, Martin Gruebele, Zaida Luthey-Schulten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007717