Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis

We describe a human nasal epithelial (HNE) organoid model derived directly from patient samples that is well-differentiated and recapitulates the airway epithelium, including the expression of cilia, mucins, tight junctions, the cystic fibrosis transmembrane conductance regulator (CFTR), and ionocyt...

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Bibliographic Details
Main Authors: Zhongyu Liu, Justin D. Anderson, Lily Deng, Stephen Mackay, Johnathan Bailey, Latona Kersh, Steven M. Rowe, Jennifer S. Guimbellot
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
cystic fibrosis
CFTR
human nasal epithelial cells
organoids
biomarker
functional assay
Online Access:https://www.mdpi.com/2073-4425/11/6/603

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https://www.mdpi.com/2073-4425/11/6/603

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