From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology

From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology

Abstract Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monokines, cytokines and interleukins. In rheumatology, early in the 1930s, synovial cel...

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Bibliographic Details
Main Author: Jean-Michel Dayer
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Auto-inflammatory diseases
Collagenase
Mononuclear cell factor
IL-1
IL-1Ra
Online Access:http://link.springer.com/article/10.1186/s13075-018-1607-y

Internet

http://link.springer.com/article/10.1186/s13075-018-1607-y

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