Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats

General anesthetics are neurotoxic to neonatal rodents and nonhuman primates. Neonatal exposure to general anesthetics has been associated with long-term cognitive deficits in animal models. Some data from humans are consistent with long-term deleterious effects of anesthetic exposure early in life...

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Bibliographic Details
Main Authors: Kathy L Murphy, Mark G Baxter
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Neurology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00087/full