Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma

A paucity of advances in the development of novel therapeutic agents for squamous cell carcinomas of the head and neck, oral cavity (OSCC) and oropharynx, has stagnated disease free survival rates over the past two decades. Although immunotherapies targeted against checkpoint inhibitors such as PD-1...

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Bibliographic Details
Main Authors: Priyanka Shah O’Brien, Yue Xi, Justin R. Miller, Amy L. Brownell, Qinghua Zeng, George H. Yoo, Danielle M. Garshott, Matthew B. O’Brien, Anthony E. Galinato, Peter Cai, Neha Narula, Michael U. Callaghan, Randal J. Kaufman, Andrew M. Fribley
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
HNSCC
head and neck cancer
high throughput screen
HTS
Antabuse
disulfiram
NSC-1771
ROS
unfolded protein response
ER stress
OSCC
oral cancer
Online Access:https://www.mdpi.com/2077-0383/8/5/611

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https://www.mdpi.com/2077-0383/8/5/611

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