Anti-Diabetic Effect of a Shihunine-Rich Extract of <i>Dendrobium</i> <i>loddigesii</i> on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK–GLUT4–PPARα

Anti-Diabetic Effect of a Shihunine-Rich Extract of <i>Dendrobium</i> <i>loddigesii</i> on 3T3-L1 Cells and db/db Mice by Up-Regulating AMPK–GLUT4–PPARα

The stems of <i>Dendrobium loddigesii</i>, a Chinese herb, are often used to treat diabetes and its polar extract is rich in shihunine, a water-soluble <i>Orchidaceae</i> alkaloid, but little is known about the anti-diabetes effects and mechanism of shihunine. This study inve...

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Bibliographic Details
Main Authors: Xue-Wen Li, Meixiang Huang, Kakei Lo, Wei-Li Chen, Ying-Yan He, Yongli Xu, Huizhen Zheng, Haiyan Hu, Jun Wang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
shihunine-rich extract of <i>Dendrobium loddigesii</i>
type 2 diabetes mellitus
db/db mice
3T3-L1 cells
cleaved caspase-3/AMPK/GLUT4/PPARα
toxic activity
Online Access:https://www.mdpi.com/1420-3049/24/14/2673

Internet

https://www.mdpi.com/1420-3049/24/14/2673

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