Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats

Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats

Intervertebral disc (IVD) disease, which is characterised by age-related changes in the adult disc, is the most common cause of disc failure and low back pain. The purpose of this study was to analyse the potential of the biologically active polyphenol epigallocatechin 3-gallate (EGCG) for the treat...

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Bibliographic Details
Main Authors: O Krupkova, M Sekiguchi, J Klasen, O Hausmann, S Konno, SJ Ferguson, K Wuertz-Kozak
Format: Article
Language:English
Published: AO Research Institute Davos 2014-11-01
Series:European Cells & Materials
Subjects:
Epigallocatechin 3-gallate
intervertebral disc degeneration
low back pain
IRAK-1
p38
NF-κB
inflammation
radiculopathy
EGCG
Online Access:http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a26.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a26.pdf

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