The Utility of Resolving Asthma Molecular Signatures Using Tissue-Specific Transcriptome Data

The Utility of Resolving Asthma Molecular Signatures Using Tissue-Specific Transcriptome Data

An integrative analysis focused on multi-tissue transcriptomics has not been done for asthma. Tissue-specific DEGs remain undetected in many multi-tissue analyses, which influences identification of disease-relevant pathways and potential drug candidates. Transcriptome data from 609 cases and 196 co...

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Bibliographic Details
Main Authors: Debajyoti Ghosh, Lili Ding, Jonathan A. Bernstein, Tesfaye B. Mersha
Format: Article
Language:English
Published: Oxford University Press 2020-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
asthma transcriptome
tissue-specific analysis
machine learning
pathways/networks
gwas catalog
connectivity map
ilincs
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401718

Internet

http://g3journal.org/lookup/doi/10.1534/g3.120.401718

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