Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modeling and Radiation Dose Optimization

Patient-Derived Nasopharyngeal Cancer Organoids for Disease Modeling and Radiation Dose Optimization

Effective radiation treatment (RT) for recurrent nasopharyngeal cancers (NPC), featuring an intrinsic hypoxic sub-volume, remains a clinical challenge. Lack of disease‐specific in-vitro models of NPC, together with difficulties in establishing patient derived xenograft (PDX) models, have further hin...

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Bibliographic Details
Main Authors: Sasidharan Swarnalatha Lucky, Martin Law, Ming Hong Lui, Jamie Mong, Junli Shi, Sidney Yu, Do Kun Yoon, Shih Kien Djeng, Jiguang Wang, Chwee Ming Lim, Min Han Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
recurrent NPC
organoids model
radioresistance
oxygen enhancement ratio
hypoxia
linear quadratic model
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.622244/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.622244/full

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