Selection of mesenchymal-like metastatic cells in primary tumors – an in silico investigation

Selection of mesenchymal-like metastatic cells in primary tumors – an in silico investigation

In order to metastasize, cancer cells must undergo phenotypic transition from an anchorage-dependent form to a motile form via a process referred to as epithelial to mesenchymal transition (EMT). It is currently unclear whether metastatic cells emerge late during tumor progression by successive accu...

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Bibliographic Details
Main Authors: Vipin eNarang, Shek Yoon eWong, Shiang Rong eLeong, Bindu eHarish, Jean-Pierre eAbastado, Alexandre eGouaillard
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Immunology
Subjects:
Tumor Microenvironment
complex systems
agent-based modeling and simulation
epithelial to mesenchymal transformation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00088/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00088/full

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