Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation

Abstract Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammatory cascade that eventually results in neuronal dysfunc...

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Bibliographic Details
Main Authors: Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Amylin receptor
β-amyloid
AC253 peptide
Inflammasome
NLRP3
Online Access:http://link.springer.com/article/10.1186/s12974-017-0972-9

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http://link.springer.com/article/10.1186/s12974-017-0972-9

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