Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease

Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease

Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) gene, one of the most common genetic for...

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Bibliographic Details
Main Authors: Lindsey M. Crown, Mitchell J. Bartlett, Jean-Paul L. Wiegand, Allison J. Eby, Emily J. Monroe, Kathleen Gies, Luke Wohlford, Matthew J. Fell, Torsten Falk, Stephen L. Cowen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
prodromal
LRRK2
sleep spindles
sleep fragmentation
EEG
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00324/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00324/full

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