Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each day, representing the most common type of DNA damage. Unrepaired SSBs compromise DNA replication and transcription programs, leading to genome instability. Unrepaired SSBs are associated with diseases such as cancer...

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Bibliographic Details
Main Authors: Md. Akram Hossain, Yunfeng Lin, Shan Yan
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
APE2
ATR-Chk1 DDR pathway
Genome integrity
SSB end resection
SSB repair
SSB signaling
Online Access:http://www.mdpi.com/1422-0067/19/8/2389

Internet

http://www.mdpi.com/1422-0067/19/8/2389

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