Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.

Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.

BACKGROUND: Beneficial effects of nicorandil on the treatment of hypertensive heart failure (HF) and ischemic heart disease have been suggested. However, whether nicorandil has inhibitory effects on HF and ventricular arrhythmias caused by the activation of G protein alpha q (Gα(q)) -coupled recepto...

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Main Authors: Masamichi Hirose, Yasuchika Takeishi, Tsutomu Nakada, Hisashi Shimojo, Toshihide Kashihara, Ayako Nishio, Satoshi Suzuki, Ulrike Mende, Kiyoshi Matsumoto, Naoko Matsushita, Eiichi Taira, Fumika Sato, Mitsuhiko Yamada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527603?pdf=render

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http://europepmc.org/articles/PMC3527603?pdf=render

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