The role of bystander effects in the antitumor activity of the hypoxia-activated prodrug PR-104

The role of bystander effects in the antitumor activity of the hypoxia-activated prodrug PR-104

Activation of prodrugs in tumors (e.g. by bioreduction in hypoxic zones) has the potential to generate active metabolites that can diffuse within the tumor microenvironment. Such ‘bystander effects’ may offset spatial heterogeneity in prodrug activation but the relative importance of this effect is...

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Bibliographic Details
Main Authors: Annika eFoehrenbacher, Kashyap ePatel, Maria eAbbattista, Chris P. Guise, Timothy W. Secomb, William R. Wilson, Kevin O. Hicks
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Oncology
Subjects:
Bystander Effect
anticancer prodrugs
hypoxia-activated prodrugs
PR-104
extravascular drug transport
multicellular layers
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00263/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00263/full

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