Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology.

Many organs, including salivary glands, lung, and kidney, are formed by epithelial branching during embryonic development. Branching morphogenesis occurs via either local outgrowths or the formation of clefts that subdivide epithelia into buds. This process is promoted by various factors, but the me...

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Bibliographic Details
Main Authors: Aya Obana-Koshino, Hitomi Ono, Jiro Miura, Manabu Sakai, Hitoshi Uchida, Wataru Nakamura, Kanji Nohara, Yusuke Maruyama, Atsuhiko Hattori, Takayoshi Sakai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4398443?pdf=render