Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

• Main Authors: Hualiang Jiang, Jian Li, Xin Xie, Yu Zhang, Jin Zhu, Kunqian Yu, Enkun Zhou, Yanqing Liu
• Format: Article
• Language: English
• Published: MDPI AG 2008-10-01
• Series: Molecules
• Subjects: CCR5 antagonist; fragment assembly; HIV-1; molecular modeling
• Online Access: http://www.mdpi.com/1420-3049/13/10/2426/

CCR5, as the major co-receptor for HIV-1 entry, is an attractive novel target for the pharmaceutical industry in the HIV-1 therapeutic area. In this study, based on the structures of maraviroc and 1,4-bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)butane-1,4-dione (1), which was identified using structure-based virtual screening in conjunction with a calcium mobilization assay, a series of novel small molecule CCR5 antagonists have been designed and synthesized through fragment assembly. Preliminary SARs were obtained, which are in good agreement with the molecular binding model and should prove helpful for future antagonist design. The novel scaffold presented here might also be useful in the development of maraviroc-derived second generation CCR5 antagonists.