Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

CCR5, as the major co-receptor for HIV-1 entry, is an attractive novel target for the pharmaceutical industry in the HIV-1 therapeutic area. In this study, based on the structures of maraviroc and 1,4-bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)butane-1,4-dione (1), which was identified using struct...

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Bibliographic Details
Main Authors: Hualiang Jiang, Jian Li, Xin Xie, Yu Zhang, Jin Zhu, Kunqian Yu, Enkun Zhou, Yanqing Liu
Format: Article
Language:English
Published: MDPI AG 2008-10-01
Series:Molecules
Subjects:
CCR5 antagonist
fragment assembly
HIV-1
molecular modeling
Online Access:http://www.mdpi.com/1420-3049/13/10/2426/

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http://www.mdpi.com/1420-3049/13/10/2426/

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