A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy

A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy

It remains undefined whether a subset of CD4+ T cells can function as fast-acting cells to control Mycobacterium tuberculosis (Mtb) infection. Here we show that the primary CD4+CD161+ T-cell subset, not CD4+CD161-, in unexposed healthy humans fast acted as unconventional T cells capable of inhibitin...

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Bibliographic Details
Main Authors: Rui Yang, Ying Peng, Jiang Pi, Yidian Liu, Enzhuo Yang, Xiaona Shen, Lan Yao, Ling Shen, Robert L. Modlin, Hongbo Shen, Wei Sha, Zheng W. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
CD4+CD161+ T cells
killing intracellular bacteria
IFN-γ
perforin
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.599641/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.599641/full

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