A high throughput mutagenic analysis of yeast sumo structure and function.

A high throughput mutagenic analysis of yeast sumo structure and function.

Sumoylation regulates a wide range of essential cellular functions through diverse mechanisms that remain to be fully understood. Using S. cerevisiae, a model organism with a single essential SUMO gene (SMT3), we developed a library of >250 mutant strains with single or multiple amino acid substi...

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Bibliographic Details
Main Authors: Heather A Newman, Pamela B Meluh, Jian Lu, Jeremy Vidal, Caryn Carson, Elizabeth Lagesse, Jeffrey J Gray, Jef D Boeke, Michael J Matunis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5319795?pdf=render

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http://europepmc.org/articles/PMC5319795?pdf=render

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