Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

<p>Abstract</p> <p>Background</p> <p>In the vascular system, Notch receptors and ligands are expressed mainly on arteries, with Delta-like 4 (Dll4) being the only ligand known to be expressed early during the development of arterial endothelial cells and capillaries. &l...

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Bibliographic Details
Main Authors: Rossant Janet, da Costa Luis, Henrique Domingos, Hirashima Masanori, Trindade Alexandre, Benedito Rui, Gill Parkash S, Duarte António
Format: Article
Language:English
Published: BMC 2008-12-01
Series:BMC Developmental Biology
Online Access:http://www.biomedcentral.com/1471-213X/8/117