c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)−17 and IL-22. However, CCR6- ILC3s additionally co-express T-bet allowing for the acquisition of type 1 effector functions. While T-bet controls the type 1 prog...

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Bibliographic Details
Main Authors: Caroline Tizian, Annette Lahmann, Oliver Hölsken, Catalina Cosovanu, Michael Kofoed-Branzk, Frederik Heinrich, Mir-Farzin Mashreghi, Andrey Kruglov, Andreas Diefenbach, Christian Neumann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
innate lymphoid cells
transcriptional regulation
ILC3 plasticity
Online Access:https://elifesciences.org/articles/52549

Internet

https://elifesciences.org/articles/52549

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