Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD

Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD

Alzheimer’s disease (AD) is the most common form of neurodegeneration and cognitive dysfunction in the elderly. Identifying molecular signals that mitigate and reverse neurodegeneration in AD may be exploited therapeutically. Transgenic AD mice (PSAPP) exhibit learning and memory deficits at 9 and 1...

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Bibliographic Details
Main Authors: Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
caveolin-1
membrane lipid raft
MLRs
gene therapy
PSAPP
Alzheimer’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000619

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http://www.sciencedirect.com/science/article/pii/S2329050121000619

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