Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome

Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome

Abstract Background Viral myocarditis (VMC) is a type of cardiac inflammation that is generally caused by coxsackievirus B3 (CVB3) infection. Several MicroRNAs (miRNAs) are known to play crucial roles in VMC pathogenesis. MiR-15 is reportedly associated with myocardial injury, inflammatory responses...

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Bibliographic Details
Main Authors: Ru Tong, Tiewen Jia, Ruijie Shi, Futang Yan
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
Coxsackievirus B3
Viral myocarditis
MiR-15
NLRX1
NLRP3 inflammasome
Online Access:http://link.springer.com/article/10.1186/s11658-020-00203-2

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http://link.springer.com/article/10.1186/s11658-020-00203-2

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