TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling.

TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling.

Triggering receptor expressed on myeloid cells 2 (TREM2) serves as an anti-inflammatory receptor, negatively regulating the innate immune response. TREM2 is mainly expressed on dendritic cells and macrophages, the target cells of porcine reproductive and respiratory syndrome virus (PRRSV). Thus, we...

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Bibliographic Details
Main Authors: Zhenbang Zhu, Xiaoxiao Zhang, Wenjuan Dong, Xiaoying Wang, Sheng He, Hui Zhang, Xun Wang, Ruiping Wei, Yaosheng Chen, Xiaohong Liu, Chunhe Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008543

Internet

https://doi.org/10.1371/journal.ppat.1008543

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