A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus

A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus

Influenza A virus infections cause significant morbidity and mortality, and novel antivirals are urgently needed. Influenza RNA-dependent RNA polymerase (RdRp) activity has been acknowledged as a promising target for novel antivirals. In this study, a phenotypic versus target-based screening strateg...

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Bibliographic Details
Main Authors: Xiujuan Zhao, Yanyan Wang, Qinghua Cui, Ping Li, Lin Wang, Zinuo Chen, Lijun Rong, Ruikun Du
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
Influenza A virus
phenotypic screen
target-based screen
RNA dependent RNA polymerase inhibitor
Online Access:https://www.mdpi.com/1999-4915/11/9/826

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https://www.mdpi.com/1999-4915/11/9/826

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