Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Abstract Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infection is also associated with the inflammatory tumor...

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Bibliographic Details
Main Authors: Yoshiki Okita, Minoru Koi, Koki Takeda, Ryan Ross, Bhramar Mukherjee, Erika Koeppe, Elena M. Stoffel, Joseph A. Galanko, Amber N. McCoy, Temitope O. Keku, Yoshinaga Okugawa, Takahito Kitajima, Yuji Toiyama, Eric Martens, John M. Carethers
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Gut Pathogens
Subjects:
Fusobacterium nucleatum
Colorectal cancer
Microsatellite instability
CpG island methylator phenotype
MSI-L
EMAST
Online Access:http://link.springer.com/article/10.1186/s13099-020-00384-3

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http://link.springer.com/article/10.1186/s13099-020-00384-3

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