Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also activates TLR4 signaling, but it is unknown if heme interacts with MD-2. Therefore, we examined MD-2 for a potential heme activation site. Heme-agaro...

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Bibliographic Details
Main Authors: John D. Belcher, Ping Zhang, Julia Nguyen, Zachary M. Kiser, Karl A. Nath, Jianjun Hu, John O. Trent, Gregory M. Vercellotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
MD-2
TLR4
heme
LPS
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01370/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01370/full

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