Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

The pneumococcal Pilus-1 enhances attachment to epithelial cells in the respiratory tract and subsequent invasion. Pilus-1 expression is bi-stable and positively regulated by the RlrA transcriptional regulator. To delineate the role of pilus-1 in Experimental Otitis Media (EOM), we evaluated coloniz...

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Bibliographic Details
Main Authors: Marisol Figueira, Monica Moschioni, Gabriella De Angelis, Michèle Barocchi, Vishakha Sabharwal, Vega Masignani, Stephen I Pelton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885439?pdf=render

Internet

http://europepmc.org/articles/PMC3885439?pdf=render

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