Evolutionary Analysis Provides Insight Into the Origin and Adaptation of HCV

Evolutionary Analysis Provides Insight Into the Origin and Adaptation of HCV

Hepatitis C virus (HCV) belongs to the Hepacivirus genus and is genetically heterogeneous, with seven major genotypes further divided into several recognized subtypes. HCV origin was previously dated in a range between ∼200 and 1000 years ago. Hepaciviruses have been identified in several domestic a...

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Bibliographic Details
Main Authors: Diego Forni, Rachele Cagliani, Chiara Pontremoli, Uberto Pozzoli, Jacopo Vertemara, Luca De Gioia, Mario Clerici, Manuela Sironi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
hepatitis C virus
equine hepacivirus
molecular dating
tMRCA
positive selection
resistance-associated amino acid variants
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00854/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00854/full

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